4 edition of The effects of cannabinoid enantiomers on the cystoskeleton of pheochromocytoma cells (PC-12 cells) found in the catalog.
The effects of cannabinoid enantiomers on the cystoskeleton of pheochromocytoma cells (PC-12 cells)
Wilson, Ronald George, Jr.
Thesis (M.Sc.)--University of Toronto, 1993.
|Series||Canadian theses = Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative.|
What is the cannabinoid mode of function in cells? the tolerance that develops to the effects of exogenous cannabinoids is probably dependent upon gene transcription Book. B-cells . Normal B-cells would be spared due to the inconsiderable expression of the CB 1 and the requirement of the ligation of both CB 1 and CB 2 to cause the desirable effects . Cannabinoid receptor ligands Natural as well as endogenous and synthetic cannabinoids are proper candidates for ligation to cannabinoid receptors.
In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters. In this study, we examined the effect of treatment with the synthetic cannabinoid, HU, on CB1 receptor density in the brain and on body weight in adolescent male rats. Rats were treated daily w 50, or μg/kg HU for 4 or 14 days, or received a single dose of μg/kg HU and sacrificed 24 h by:
Pheochromocytoma by Anonymous. My medicinal marijuana story began ever so innocently in After suffering debilitating migraines (or so they thought) for going on 5 years, I was at my wits end when I friend suggested I try smoking a little pot. The effect smoking had on my headaches was unbelievable. Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM and AM reveal notable structural rearrangements upon receptor activation, and this flexibility may be Cited by:
He leadeth me
Views on France.
moments anger, a lifes sorrow
Minutes of the Five Years Meeting of the Friends in America
Milan and his runaway uncle.
Direct and Indirect Boundary Integral Equation Methods (Chapman and Hall /Crc Monographs and Surveys in Pure and Applied Mathematics)
Practical aspects of memory: Current research & issues: Vol.1: Memory in everyday life.
Reviews of national science policy.
The effects of these synthetic cannabinoids on the cytoskeleton of PC‐12 cells were examined by epifluorescence and confocal microscopy. In both undifferentiated and differentiating PC‐12 cells, HU‐ has little effect on the cytoarchitecture whereas HU‐ disrupts the distribution of microtubules and by: The effects of these synthetic cannabinoids on the cytoskeleton of PC cells were examined by epifluorescence and confocal microscopy.
In both undifferentiated and differentiating PC cells, HU has little effect on the cytoarchitecture whereas HU disrupts the distribution of microtubules and by: Deep infiltrating endometriosis (DIE) is characterized by chronic pain, hyperproliferation of endometriotic cells and fibrosis.
Since cannabinoids are endowed with antiproliferative and antifibrotic properties, in addition to their psychogenic and analgesic effects, cannabinoid agonists have been evaluated in DIE both in vitro and in in vitro effects of the cannabinoid Cited by: Effects of solvent (SOL), WIN (WIN-2), WIN (WIN-3) and CP (CP) on the plasma adrenaline concentration in pithed rabbits with electrically stimulated sympathetic outflow.
SOL ( ml kg−1), WIN-2 (5, 50 and μg kg Rabbit isolated adrenal by: Marijuana and cannabinoids have been shown to exert profound effects on hypothalamic regulatory functions and reproduction in both experimental animals and humans.
Here we review the role of (endo) cannabinoids in the regulation of appetite and food by: Conclusions. Cannabinoids exert a number of interesting effects that are dependent on the cell line or tumor type. Synthetic cannabinoids and the endocannabinoid system are implicated in inhibiting cancer cell proliferation and angiogenesis, reducing tumor growth and metastases, and inducing by: In the present study, mouse neuroblastoma N1E cells were used as an in vitro model to investigate cannabinoid-induced neurite remodeling effects and to identify the involvement of cannabinoid.
immune cells do express cannabinoid receptors and therefore, the modulating effects of cannabinoids are being reexamined in the context of cannabinoid receptor function.
Cell viability and Proliferation. Cells grown for 24 h at a density of 1 × 10 4 cells per µl of complete medium in well plate were incubated with JWH/Win55, (1–20 µM) (Tocris Cookson, Ellisville, MO) for 24 h. Cell viability was determined by the CellTiter 96 Aqueous One Solution Reagent (MTS, Promega, Madison, WI), according to the manufacturer's by: Researchers have been studying how the compounds in the Cannabis plant act on individual cells, both in the brain and elsewhere in the body.
This knowledge is crucial to determining exactly how cannabis and its constituents affect users. Studies indicate that cannabinoids produce most of their effects by binding to proteins, called receptors, on the. Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage.
Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by an enhanced superoxide production by the vascular endothelium with its Cited by: Cannabinoid receptor-2 (CB2) is expressed dominantly in the immune system, especially on plasma cells.
Cannabinergic ligands with CB2 selectivity emerge as. In the presence of colchicine and cytochalasin D compounds which destabilize the cytoarchitecture, cells are more susceptible to the disrupting effects of hydrostatic pressure.
The effects of hydrostatic pressure on cell morphology were by: Acid metabolites from in vivo metabolism. The most widely studied cannabinoid acid is Δ 9 –THCoic acid (Fig.
2, D).It is the terminal metabolite of Δ 9 –THC (Fig. 2, A) that is generated in a three-stage process going through the hydroxyl (Fig. 2, B) and aldehyde (Fig. 2, C) route occurs in humans and in every other species Cited by: In a few experiments, the effects of WIN‐2 were compared with the effects of WIN‐3, the enantiomer of WIN‐2, which in binding studies has very low affinity for cannabinoid receptors, and with the effects of CP, a mixed CB 1 /CB 2 cannabinoid receptor agonist with a chemical structure markedly different from WIN‐ by: Cannabis, cannabinoids and reproduction.
Book. Full-text available. (direct cytotoxic damage to the testicular germinal epithelium and/or cells of Leydig), and post-testicular effects.
Cannabinoid receptors are found throughout the body. There are generally two types: CB1 and CB2. The CB1 is often called the central cannabinoid receptor, because it is the predominant form in the brain/CNS. The CB2 receptor is often called the peripheral cannabinoid receptor, because it is found mostly outside the CNS.
The impact of exogenous cannabinoids on mitochondrial processes has been proposed since the Seventies , long before the discovery of cannabinoid receptors .
With the identiﬁcation of cannabinoid receptors as typical plasma membrane receptors [17,18], the mito-chondrial effects of cannabinoids were interpreted either as indirect.
This chapter summarizes the current clinical and experimental data related to the effect of cannabis and/or cannabinoids on motor dysfunction in basal ganglia movement disorders. In patients with Parkinson disease (PD), there are data to suggest some benefit for cannabis or cannabis-based medicines on motor symptoms and l -dopa-induced : O.M.E.
Abdel-Salam. Introduction. Δ 9-tetrahydrocannabinol (THC), the main active component of Cannabis sativa exerts its effects by mimicking endogenous substances – the endocannabinoids anandamide (Devane et al., ) and 2-arachidonoylglycerol (2-AG) (Mechoulam et al.,Sugiura et al., ) – that bind specific cannabinoid receptors located in the plasma membrane (Pertwee Cited by:.
The CB 2 ‐specificity of the effects of R,S‐AM and its enantiomers was demonstrated by the absence of effects on forskolin‐stimulated cAMP in parental CHO‐K1 cells (data not shown).
The effects of all three ligands in all three CB 2 ‐expressing cells were sensitive to Pertussis toxin (data not shown), indicating that the observed Cited by: The effect of CBG on CRC (Caco-2) cells viability is modulated by a CB 2 receptor antagonist and does not involve TRPA1, TRPV1 and TRPV2 channels.
Since CBG is a constituent of Cannabis, we verified if its effect on Caco-2 cell viability was affected by selective CB 1 and CB 2 receptor by: clear if cannabinoids have a direct or indirect effect on B cells; however, the biphasic role of cannabinoids has also been shown in B cell studies.
Derocq et al. () demonstrated increased B cell proliferation as a response to THC and CP55,; whereas Klein et al. () showed decreased response to LPS by B cells upon cannabinoid treatment.